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EFHD2 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q96C19
Clone Names 91113133
Additional Information
Other Names EF-hand domain-containing protein D2, Swiprosin-1, EFHD2, SWS1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9285b was selected from the C-term region of human EFHD2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name EFHD2
Synonyms SWS1
Function May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.
Cellular Location Membrane raft. Note=In a mouse immature B-cell line WEHI-231.
Tissue Location Found in lymphocytes; preferentially expressed in CD8+ cells. EMBL; AL031283; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471167; EAW51720.1; -; Genomic_DNA EMBL; BC007233; AAH07233.1; -; mRNA EMBL; BC014923; AAH14923.1; -; mRNA EMBL; BC023611; AAH23611.1; -; mRNA EMBL; BC068473; AAH68473.1; -; mRNA CCDS; CCDS155.1; - RefSeq; NP_077305.2; NM_024329.5 PDB; 5H0P; X-ray; 1.86 A; A=70-184 PDB; 5I2L; X-ray; 1.85 A; A=70-184 PDB; 5I2O; X-ray; 1.95 A; A=70-184 PDB; 5I2Q; X-ray; 1.94 A; A=70-184 PDBsum; 5H0P; - PDBsum; 5I2L; - PDBsum; 5I2O; - PDBsum; 5I2Q; - SMR; Q96C19; - BioGRID; 122597; 59 IntAct; Q96C19; 19 MINT; Q96C19; - STRING; 9606.ENSP00000365147; - iPTMnet; Q96C19; - MetOSite; Q96C19; - PhosphoSitePlus; Q96C19; - SwissPalm; Q96C19; - BioMuta; EFHD2; - DMDM; 20140139; - REPRODUCTION-2DPAGE; IPI00060181; - SWISS-2DPAGE; Q96C19; - EPD; Q96C19; - jPOST; Q96C19; - MassIVE; Q96C19; - MaxQB; Q96C19; - PaxDb; Q96C19; - PeptideAtlas; Q96C19; - PRIDE; Q96C19; - ProteomicsDB; 76150; - TopDownProteomics; Q96C19; - Antibodypedia; 28833; 160 antibodies Ensembl; ENST00000375980; ENSP00000365147; ENSG00000142634 GeneID; 79180; - KEGG; hsa:79180; - UCSC; uc001awh.2; human CTD; 79180; - DisGeNET; 79180; - EuPathDB; HostDB:ENSG00000142634.12; - GeneCards; EFHD2; - HGNC; HGNC:28670; EFHD2 HPA; ENSG00000142634; Low tissue specificity MIM; 616450; gene neXtProt; NX_Q96C19; - OpenTargets; ENSG00000142634; - PharmGKB; PA134942316; - eggNOG; KOG0041; Eukaryota eggNOG; ENOG4111JG9; LUCA GeneTree; ENSGT00390000012058; - HOGENOM; CLU_094429_0_0_1; - InParanoid; Q96C19; - KO; K23922; - OMA; NEGIGEH; - OrthoDB; 1511376at2759; - PhylomeDB; Q96C19; - TreeFam; TF320736; - BioGRID-ORCS; 79180; 16 hits in 787 CRISPR screens ChiTaRS; EFHD2; human GenomeRNAi; 79180; - Pharos; Q96C19; Tbio PRO; PR:Q96C19; - Proteomes; UP000005640; Chromosome 1 RNAct; Q96C19; protein Bgee; ENSG00000142634; Expressed in blood and 204 other tissues ExpressionAtlas; Q96C19; baseline and differential Genevisible; Q96C19; HS GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell GO; GO:0045296; F:cadherin binding; HDA:BHF-UCL GO; GO:0005509; F:calcium ion binding; IEA:InterPro CDD; cd00051; EFh; 1 InterPro; IPR011992; EF-hand-dom_pair InterPro; IPR002048; EF_hand_dom InterPro; IPR040365; EFHD1/2 PANTHER; PTHR13025; PTHR13025; 1 Pfam; PF13405; EF-hand_6; 1 SMART; SM00054; EFh; 2 SUPFAM; SSF47473; SSF47473; 1 PROSITE; PS50222; EF_HAND_2; 2 1: Evidence at protein level; 3D-structure; Acetylation; Calcium; Direct protein sequencing; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Repeat INIT_MET 1 /note="Removed" /evidence="ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:22814378, ECO:0000269|Ref.4" CHAIN 2..240 /note="EF-hand domain-containing protein D2" /id="PRO_0000073645" DOMAIN 92..127 /note="EF-hand 1" /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" DOMAIN 128..163 /note="EF-hand 2" /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" CA_BIND 105..116 /note="1" /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" CA_BIND 141..152 /note="2" /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" MOD_RES 2 /note="N-acetylalanine" /evidence="ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:22814378, ECO:0000269|Ref.4" MOD_RES 11 /note="Phosphoserine" /evidence="ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:23186163" MOD_RES 74 /note="Phosphoserine" /evidence="ECO:0000244|PubMed:16964243, ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:19690332, ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:23186163, ECO:0000244|PubMed:24275569" MOD_RES 76 /note="Phosphoserine" /evidence="ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:23186163, ECO:0000244|PubMed:24275569" MOD_RES 83 /note="Phosphotyrosine" /evidence="ECO:0000250|UniProtKB:Q9D8Y0" MOD_RES 233 /note="N6-acetyllysine" /evidence="ECO:0000244|PubMed:19608861" HELIX 82..85 /evidence="ECO:0000244|PDB:5I2L" HELIX 91..104 /evidence="ECO:0000244|PDB:5I2L" STRAND 109..112 /evidence="ECO:0000244|PDB:5I2L" HELIX 114..124 /evidence="ECO:0000244|PDB:5I2L" HELIX 130..140 /evidence="ECO:0000244|PDB:5I2L" STRAND 145..149 /evidence="ECO:0000244|PDB:5I2L" HELIX 150..161 /evidence="ECO:0000244|PDB:5I2L" HELIX 170..177 /evidence="ECO:0000244|PDB:5I2L" SEQUENCE 240 AA; 26697 MW; 9FE3FEC3007A8FC2 CRC64; MATDELATKL SRRLQMEGEG GGETPEQPGL NGAAAAAAGA PDEAAEALGS ADCELSAKLL RRADLNQGIG EPQSPSRRVF NPYTEFKEFS RKQIKDMEKM FKQYDAGRDG FIDLMELKLM MEKLGAPQTH LGLKNMIKEV DEDFDSKLSF REFLLIFRKA AAGELQEDSG LCVLARLSEI DVSSEGVKGA KSFFEAKVQA INVSSRFEEE IKAEQEERKK QAEEMKQRKA AFKELQSTFK
Research Areas
Citations (0)

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Background

EFHD2 may regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. EFHD2 plays a role as negative regulator of the canonical NF-kappa-B-activating branch. This protein controls spontaneous apoptosis through the regulation of BCL2L1 abundance.

References

Thylur,R.P., et.al., J. Cell. Biochem. 108 (3), 705-715 (2009)Martins-de-Souza,D., et.al., Eur Arch Psychiatry Clin Neurosci 259 (3), 151-163 (2009)Avramidou,A., et.al., Cell Death Differ. 14 (11), 1936-1947 (2007)

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$ 277.78
Cat# BP9285b
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