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EFHD2 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q96C19 |
| Reactivity | Rat, Pig, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 27 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human EFHD2 |
| Epitope Specificity | 51-150/240 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Membrane raft. In immature B-cell line WEHI231. |
| SIMILARITY | Contains 2 EF-hand domains. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | EFHD2 is a 240 amino acid protein that regulates spontaneous apoptosis through the regulation of Bcl-xS abundance. Localized to membrane raft, Swiprosin-1 is expressed in lymphocytes and contains two EF-hand domains. The gene encoding Swiprosin-1 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma. |
| Gene ID | 79180 |
|---|---|
| Other Names | EF-hand domain-containing protein D2, Swiprosin-1, EFHD2, SWS1 |
| Target/Specificity | Found in lymphocytes; preferentially expressed in CD8+ cells. |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | EFHD2 |
|---|---|
| Synonyms | SWS1 |
| Function | May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance. |
| Cellular Location | Membrane raft. Note=In a mouse immature B-cell line WEHI-231. |
| Tissue Location | Found in lymphocytes; preferentially expressed in CD8+ cells. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
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$ 385.00
Cat# AP55607
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