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Anti-PCK Antibody (Monoclonal, C-11+PCK-26+CY-90+KS-1A3+M20+A53-B/A2)
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Application 
| WB, IHC-P, IHC-F |
|---|---|
| Primary Accession | P04264 |
| Host | Mouse |
| Isotype | Mouse IgG2a/ IgG1 |
| Reactivity | Human, Rat |
| Clonality | Monoclonal |
| Format | Lyophilized |
| Description | Mouse IgG monoclonal antibody for PCK detection. Tested with WB, IHC-P, IHC-F in Human;rat. No cross reactivity with other proteins. |
| Reconstitution | Add 1ml of PBS buffer will yield a concentration of 100ug/ml. |
| Gene ID | 3848 |
|---|---|
| Other Names | Keratin, type II cytoskeletal 1, 67 kDa cytokeratin, Cytokeratin-1, CK-1, Hair alpha protein, Keratin-1, K1, Type-II keratin Kb1, KRT1, KRTA |
| Calculated MW | 66039 MW KDa |
| Application Details | Immunohistochemistry(Paraffin-embedded Section), 0.1-0.5 µg/ml, Human, rat, By Heat Immunohistochemistry(Frozen Section), 0.1-0.5 µg/ml, Human, rat, - Western blot, 1-2 µg/ml, Human, rat |
| Subcellular Localization | Cell membrane . Located on plasma membrane of neuroblastoma NMB7 cells. |
| Tissue Specificity | The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis. |
| Protein Name | Keratin, type II cytoskeletal 1 |
| Contents | Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. |
| Clone Names | C-11+PCK-26+CY-90+KS-1A3+M20+A53-B/A2 |
| Immunogen | mixture of several monoclonal cytokeratin clones. |
| Purification | Ascites |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the intermediate filament family. |
| Name | KRT1 |
|---|---|
| Synonyms | KRTA |
| Function | May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK. |
| Cellular Location | Cell membrane. Cytoplasm |
| Tissue Location | The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis |
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Provided below are standard protocols that you may find useful for product applications.
Background
Monoclonal anti cytokeratins are specific markers of epithelial cell differentiation and have been widely used as tools in tumor identification and classification. Monoclonal Anti Pan Cytokeratin(mixture) is a broadly reactive reagent, which recognizes epitopes present in most human epithelial tissues.
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