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Anti-Aquaporin 3 Antibody

     
  • WB - Anti-Aquaporin 3 Antibody ABO10807
    Anti-Aquaporin 3 antibody, ABO10807, Western blottingAll lanes: Anti (ABO10807) at 0.5ug/mlLane 1: Rat Kidney Tissue Lysate at 50ugLane 2: Rat Lung Tissue Lysate at 50ugLane 3: Mouse Kidney Tissue Lysate at 50ugLane 4: MM453 Whole Cell Lysate at 40ugLane 5: SMMC-7721 Whole Cell Lysate at 40ugPredicted bind size: 32KDObserved bind size: 32KD
    detail
  • IHC - Anti-Aquaporin 3 Antibody ABO10807
    Anti-Aquaporin 3 antibody, ABO10807, IHC(P)IHC(P): Rat Kidney Tissue
    detail
  • ICC - Anti-Aquaporin 3 Antibody ABO10807
    Anti-Aquaporin 3 antibody, ABO10807, ICCICC: HELA Cell
    detail
  • IHC - Anti-Aquaporin 3 Antibody ABO10807
    Anti-Aquaporin 3 antibody, ABO10807, IHC(F)IHC(F): Rat Kidney Tissue
    detail
  • IHC - Anti-Aquaporin 3 Antibody ABO10807
    Anti-Aquaporin 3 antibody, ABO10807, IHC(P)IHC(P): Human Renal Cancer Tissue
    detail
  • IHC - Anti-Aquaporin 3 Antibody ABO10807
    Anti-Aquaporin 3 antibody, ABO10807, IHC(P)IHC(P): Human Lung Cancer Tissue
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IHC-F, ICC
Primary Accession Q92482
Host Rabbit
Reactivity Human, Mouse, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Aquaporin-3(AQP3) detection. Tested with WB, IHC-P, IHC-F, ICC in Human;Mouse;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 360
Other Names Aquaporin-3, AQP-3, Aquaglyceroporin-3, AQP3
Calculated MW 31544 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, Rat, Mouse, By Heat

Immunocytochemistry , 0.5-1 µg/ml, Human, Mouse, Rat
Immunohistochemistry(Frozen Section), 0.5-1 µg/ml, Rat, Human, Mouse
Western blot, 0.1-0.5 µg/ml, Human, Mouse, Rat
Subcellular Localization Basolateral cell membrane; Multi-pass membrane protein. In collecting ducts of kidney.
Tissue Specificity Widely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erythrocytes. Isoform 2 is not detectable in erythrocytes at the protein level.
Protein Name Aquaporin-3
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of human Aquaporin 3(278-292aa EENVKLAHVKHKEQI), different from the related rat and mouse sequences by one amino acid.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Sequence Similarities Belongs to the MIP/aquaporin (TC 1.A.8) family.
Protein Information
Name AQP3
Function Water channel required to promote glycerol permeability and water transport across cell membranes (PubMed:12239222, PubMed:30420639). Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P47862}. Basolateral cell membrane {ECO:0000250|UniProtKB:P47862}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P47862}
Tissue Location Widely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erythrocytes. Isoform 2 is not detectable in erythrocytes at the protein level
Research Areas
Citations (0)
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Background

This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

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$ 280.00
Cat# ABO10807
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