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> home > Products > Primary Antibodies > Signal Transduction > Anti-PTP1B PTPN1 Rabbit Monoclonal Antibody
Anti-PTP1B PTPN1 Rabbit Monoclonal Antibody
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Application 
| WB, IHC, IF, ICC, FC |
|---|---|
| Primary Accession | P18031 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-PTP1B PTPN1 Rabbit Monoclonal Antibody . Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human. |
| Gene ID | 5770 |
|---|---|
| Other Names | Tyrosine-protein phosphatase non-receptor type 1, 3.1.3.48, Protein-tyrosine phosphatase 1B, PTP-1B, PTPN1, PTP1B |
| Calculated MW | 49967 MW KDa |
| Application Details | WB 1:500-1:2000 IHC 1:50-1:100 ICC/IF 1:50-1:100 FC 1:20 |
| Subcellular Localization | Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side. Interacts with EPHA3 at the cell membrane. |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: IHG-16 |
| Immunogen | A synthesized peptide derived from human PTP1B |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | PTPN1 |
|---|---|
| Synonyms | PTP1B |
| Function | Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c- src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. |
| Cellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side Note=Interacts with EPHA3 at the cell membrane |
| Tissue Location | Expressed in keratinocytes (at protein level). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 370.00
Cat# ABO13725
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