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Anti-Smac/Diablo Rabbit Monoclonal Antibody
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Application 
| WB, IHC, IF, ICC, IP, FC |
|---|---|
| Primary Accession | Q9NR28 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-Smac/Diablo Rabbit Monoclonal Antibody . Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. |
| Gene ID | 56616 |
|---|---|
| Other Names | Diablo IAP-binding mitochondrial protein {ECO:0000312|HGNC:HGNC:21528}, Diablo homolog, mitochondrial {ECO:0000312|HGNC:HGNC:21528}, Direct IAP-binding protein with low pI {ECO:0000312|HGNC:HGNC:21528}, Second mitochondria-derived activator of caspase, Smac, Diablo IAP-binding mitochondrial protein, cleaved form, DIABLO (HGNC:21528) |
| Calculated MW | 27131 MW KDa |
| Application Details | WB 1:1000-1:5000 IHC 1:50-1:200 ICC/IF 1:100-1:500 IP 1:50 FC 1:50 |
| Subcellular Localization | Mitochondrion. Released into the cytosol when cells undergo apoptosis. |
| Tissue Specificity | Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed.. |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: FGG-4 |
| Immunogen | A synthesized peptide derived from human Smac/Diablo |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | DIABLO (HGNC:21528) |
|---|---|
| Function | Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/BRUCE by inhibiting its binding to caspases (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). |
| Cellular Location | Mitochondrion. Cytoplasm, cytosol Note=Released into the cytosol in a PARL-dependent manner when cells undergo apoptosis. |
| Tissue Location | Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed |
Research Areas
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 370.00
Cat# ABO14084
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