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> home > Products > Primary Antibodies > Stem Cells > Anti-Sonic Hedgehog SHH Rabbit Monoclonal Antibody
Anti-Sonic Hedgehog SHH Rabbit Monoclonal Antibody
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Application 
| WB, IHC, IF, ICC, FC |
|---|---|
| Primary Accession | Q15465 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-Sonic Hedgehog SHH Rabbit Monoclonal Antibody . Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human. |
| Gene ID | 6469 |
|---|---|
| Other Names | Sonic hedgehog protein, SHH, 3.1.-.-, HHG-1, Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains, ShhNC, Sonic hedgehog protein N-product, ShhN, Shh N-terminal processed signaling domains, ShhNp, SHH (HGNC:10848) |
| Calculated MW | 49607 MW KDa |
| Application Details | WB 1:500-1:2000 IHC 1:50-1:200 ICC/IF 1:50-1:200 FC 1:50 |
| Subcellular Localization | Sonic hedgehog protein C-product: Secreted, extracellular space. The C-terminal peptide diffuses from the cell.. |
| Tissue Specificity | Expressed in fetal intestine, liver, lung, and kidney. Not expressed in adult tissues. |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: ABE-19 |
| Immunogen | A synthesized peptide derived from human Sonic Hedgehog |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | SHH (HGNC:10848) |
|---|---|
| Function | [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the endoplasmic reticulum (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). |
| Cellular Location | [Sonic hedgehog protein]: Endoplasmic reticulum membrane. Golgi apparatus membrane. Secreted Note=Co-localizes with HHAT in the ER and Golgi membrane |
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Application Protocols
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$ 370.00
Cat# ABO14176
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