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Anti-Claudin 4 Monoclonal Antibody

     
  •  - Anti-Claudin 4 Monoclonal Antibody ABO14539
    Western blot analysis of Claudin 4 expression in MCF7 cell lysate.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC, IP
Primary Accession O14493
Host Rabbit
Isotype Rabbit IgG
Reactivity Human
Clonality Monoclonal
Format Liquid
Description Anti-Claudin 4 Monoclonal Antibody . Tested in WB, IHC, IP applications. This antibody reacts with Human.
Additional Information
Gene ID 1364
Other Names Claudin-4, Clostridium perfringens enterotoxin receptor, CPE-R, CPE-receptor, Williams-Beuren syndrome chromosomal region 8 protein, CLDN4
Calculated MW 22077 Da
Application Details WB 1:500-1:1000
IHC 1:100-1:500
IP 1:20
Contents Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Clone Names Clone: ADEB-3
Immunogen A synthesized peptide derived from human Claudin 4
Purification Affinity-chromatography
Storage Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Protein Information
Name CLDN4 {ECO:0000303|PubMed:35773259, ECO:0000312|HGNC:HGNC:2046}
Function Can associate with other claudins to regulate tight junction structural and functional strand dynamics (PubMed:35773259, PubMed:36008380). May coassemble with CLDN8 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts (By similarity) (PubMed:36008380). May integrate into CLDN3 strands to modulate localized tight junction barrier properties (PubMed:35773259, PubMed:36008380). May disrupt strand assembly of channel-forming CLDN2 and CLDN15 and inhibit cation conductance (PubMed:35773259, PubMed:36008380). Cannot form tight junction strands on its own (PubMed:35773259, PubMed:36008380).
Cellular Location Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
Research Areas
Citations (0)
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Background

Plays a major role in tight junction-specific obliteration of the intercellular space.

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$ 370.00
Cat# ABO14539
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