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> home > Products > Primary Antibodies > Signal Transduction > Anti-Human Emerin DyLight® 488 conjugated EMD Antibody(monoclonal, 5A10)
Anti-Human Emerin DyLight® 488 conjugated EMD Antibody(monoclonal, 5A10)
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- CITATIONS
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- BACKGROUND
Application 
| FC |
|---|---|
| Primary Accession | P50402 |
| Host | Mouse |
| Isotype | Mouse IgG1 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-Human Emerin DyLight® 488 conjugated EMD Antibody (monoclonal, 5A10) . Tested in Flow Cytometry applications. This antibody reacts with Human. |
| Gene ID | 2010 |
|---|---|
| Other Names | Emerin, EMD, EDMD, STA |
| Calculated MW | 28994 Da |
| Application Details | Flow Cytometry, 1-3 µg/1x10^6 cells |
| Subcellular Localization | Nucleus inner membrane. |
| Tissue Specificity | Skeletal muscle, heart, colon, testis, ovary and pancreas. |
| Contents | Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3. |
| Clone Names | Clone: 5A10 |
| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminus of human Emerin, different from the related mouse sequence by eight amino acids, and from the related rat sequence by nine amino acids. |
| Cross Reactivity | No cross-reactivity with other proteins. |
| Storage | At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light. |
| Name | EMD |
|---|---|
| Synonyms | EDMD, STA |
| Function | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta- catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1- dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non- farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. |
| Cellular Location | Nucleus inner membrane; Single-pass membrane protein; Nucleoplasmic side. Nucleus outer membrane. Note=Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus |
| Tissue Location | Skeletal muscle, heart, colon, testis, ovary and pancreas |
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$ 515.00
Cat# ABO14793
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