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Anti-UAP1 Rabbit Monoclonal Antibody
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Application 
| WB, IHC, IF, ICC, IP, FC |
|---|---|
| Primary Accession | Q16222 |
| Host | Rabbit |
| Isotype | IgG |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-UAP1 Rabbit Monoclonal Antibody . Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. |
| Gene ID | 6675 |
|---|---|
| Other Names | UDP-N-acetylhexosamine pyrophosphorylase, Antigen X, AGX, Protein-pyrophosphorylation enzyme, 2.7.4.-, Sperm-associated antigen 2, UDP-N-acetylgalactosamine pyrophosphorylase, 2.7.7.83, UDP-N-acetylglucosamine pyrophosphorylase, 2.7.7.23, UAP1 {ECO:0000303|PubMed:9603950, ECO:0000312|HGNC:HGNC:12457} |
| Calculated MW | 59 kDa |
| Application Details | WB 1:500-1:2000 IHC 1:50-1:200 ICC/IF 1:50-1:200 IP 1:50 FC 1:100 |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 18U25 |
| Immunogen | A synthesized peptide derived from human UAP1 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | UAP1 {ECO:0000303|PubMed:9603950, ECO:0000312|HGNC:HGNC:12457} |
|---|---|
| Function | Catalyzes the last step in biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) by converting UTP and glucosamine 1-phosphate (GlcNAc-1-P) to the sugar nucleotide (PubMed:9603950, PubMed:9765219). Also converts UTP and galactosamine 1-phosphate (GalNAc-1-P) into uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc) (PubMed:9765219). In addition to its role in metabolism, acts as a regulator of innate immunity in response to virus infection by mediating pyrophosphorylation of IRF3: catalyzes pyrophosphorylation of IRF3 phosphorylated at 'Ser-386' by TBK1, promoting IRF3 dimerization and activation, leading to type I interferon responses (PubMed:36603579). |
| Cellular Location | Cytoplasm, cytosol. Note=In spermatozoa, localized to the principal piece of the tail, the neck region of the head and to a lesser extent, the midpiece of the tail. |
| Tissue Location | Widely expressed (PubMed:8025165). Expressed at low level in placenta, muscle and liver (PubMed:8025165) [Isoform AGX2]: Isoform AGX2 is more abundant than isoform AGX1 in somatic tissue. |
Research Areas
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 370.00
Cat# ABO15249
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