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> home > Products > Primary Antibodies > Signal Transduction > Anti-Legumain Rabbit Monoclonal Antibody
Anti-Legumain Rabbit Monoclonal Antibody
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Application 
| WB |
|---|---|
| Primary Accession | Q99538 |
| Host | Rabbit |
| Isotype | IgG |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-Legumain Rabbit Monoclonal Antibody . Tested in WB application. This antibody reacts with Human, Mouse, Rat. |
| Gene ID | 5641 |
|---|---|
| Other Names | Legumain, 3.4.22.34, Asparaginyl endopeptidase, AEP, Protease, cysteine 1, LGMN {ECO:0000303|PubMed:30425301, ECO:0000312|HGNC:HGNC:9472} |
| Calculated MW | 36 kDa, 57 kDa |
| Application Details | WB 1:500-1:2000 |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 23L04 |
| Immunogen | A synthesized peptide derived from human Legumain |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | LGMN {ECO:0000303|PubMed:30425301, ECO:0000312|HGNC:HGNC:9472} |
|---|---|
| Function | Has a strict specificity for hydrolysis of asparaginyl bonds (PubMed:23776206). Can also cleave aspartyl bonds slowly, especially under acidic conditions (PubMed:23776206). Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (PubMed:9872320). Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol (By similarity). Required for normal lysosomal protein degradation in renal proximal tubules (By similarity). Required for normal degradation of internalized EGFR (By similarity). Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). |
| Cellular Location | Lysosome. |
| Tissue Location | Ubiquitous. Particularly abundant in kidney, heart and placenta. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 370.00
Cat# ABO15728
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