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> home > Products > Primary Antibodies > Antibody Collections > Prostate negative > Anti-DNPH1 Rabbit Monoclonal Antibody
Anti-DNPH1 Rabbit Monoclonal Antibody
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Application 
| WB, IHC |
|---|---|
| Primary Accession | O43598 |
| Host | Rabbit |
| Isotype | IgG |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-DNPH1 Rabbit Monoclonal Antibody . Tested in WB, IHC applications. This antibody reacts with Human. |
| Gene ID | 10591 |
|---|---|
| Other Names | 5-hydroxymethyl-dUMP N-hydrolase, 3.2.2.-, 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 {ECO:0000312|HGNC:HGNC:21218}, c-Myc-responsive protein RCL, DNPH1 (HGNC:21218) |
| Calculated MW | 21 kDa |
| Application Details | WB 1:500-1:2000 IHC 1:50-1:200 |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 27D38 |
| Immunogen | A synthesized peptide derived from human DNPH1 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | DNPH1 (HGNC:21218) |
|---|---|
| Function | Part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate) (PubMed:33833118). Catalyzes the second step in that pathway, the hydrolysis of the N-glycosidic bond in hmdUMP, degrading this cytotoxic nucleotide to avoid its genomic integration (PubMed:33833118). |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Expressed at low levels in brain, colon, lung, peripheral blood leukocytes, placenta, small intestine, and thymus Expressed at high levels in heart, kidney, liver, skeletal muscle and spleen. Overexpressed in a significant proportion of breast cancers |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 370.00
Cat# ABO16159
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