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Anti-HGD Antibody Picoband™ (monoclonal, 2F11E1)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, FC |
|---|---|
| Primary Accession | Q93099 |
| Host | Mouse |
| Isotype | Mouse IgG2b |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Lyophilized |
| Description | Anti-HGD Antibody Picoband™ (monoclonal, 2F11E1) . Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human. |
| Reconstitution | Adding 0.2 ml of distilled water will yield a concentration of 500 µg/ml. |
| Gene ID | 3081 |
|---|---|
| Other Names | Homogentisate 1, 2-dioxygenase, 1.13.11.5, Homogentisate oxygenase, Homogentisic acid oxidase, Homogentisicase, HGD, HGO |
| Calculated MW | 50 kDa |
| Application Details | Western blot, 0.25-0.5 µg/ml, Human Immunohistochemistry(Paraffin-embedded Section), 2-5 µg/ml, Human Flow Cytometry, 1-3 µg/1x10^6 cells, Human |
| Contents | Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4. |
| Clone Names | Clone: 2F11E1 |
| Immunogen | E. coli-derived human HGD recombinant protein (Position: D374-N445). |
| Purification | Immunogen affinity purified. |
| Storage | At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing. |
| Name | HGD |
|---|---|
| Synonyms | HGO |
| Function | Catalyzes the conversion of homogentisate to maleylacetoacetate. |
| Tissue Location | Highest expression in the prostate, small intestine, colon, kidney and liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
The HGD gene encodes homogentisate 1,2-dioxygenase (HGD), an enzyme involved in the catabolism of phenylalanine and tyrosine. This enzyme is involved in the catabolism of the amino acids tyrosine and phenylalanine. Mutations in this gene are the cause of the autosomal recessive metabolism disorder alkaptonuria. This gene is mapped to chromosome 3q21-q23 by a preliminary PCR screen of hamster/human somatic cell hybrid genomic DNA samples and by fluorescence in situ hybridization.
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