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Anti-N4BP1 Rabbit Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q6A037 |
| Host | Rabbit |
| Isotype | IgG |
| Reactivity | Rat, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-N4BP1 Rabbit Monoclonal Antibody . Tested in WB application. This antibody reacts with Mouse, Rat. |
| Gene ID | 80750 |
|---|---|
| Other Names | NEDD4-binding protein 1, N4BP1, 3.1.-.-, N4bp1 {ECO:0000303|PubMed:11717310, ECO:0000312|MGI:MGI:2136825} |
| Calculated MW | 110 kDa |
| Application Details | WB 1:500-1:2000 |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 28N99 |
| Immunogen | A synthesized peptide derived from human N4BP1 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | N4bp1 {ECO:0000303|PubMed:11717310, ECO:0000312|MGI:MGI:2136825} |
|---|---|
| Function | Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation (PubMed:32971525). Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults (PubMed:32971525). In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (PubMed:32971525). Acts as a restriction factor against some viruses: restricts viral replication by binding to mRNA viruses and mediating their degradation via its ribonuclease activity (By similarity). Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (PubMed:17592138). |
| Cellular Location | Cytoplasm, cytosol. Nucleus. Nucleus, nucleolus. Nucleus, PML body. Note=Primarily localizes to the nucleolus (PubMed:20233849). Also localizes to the PML nuclear bodies, when desumoylated (PubMed:20233849). |
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 370.00
Cat# ABO16363
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