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Anti-EMC4 Rabbit Monoclonal Antibody
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- BACKGROUND
Application 
| WB, IHC, IP |
|---|---|
| Primary Accession | Q5J8M3 |
| Host | Rabbit |
| Isotype | IgG |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-EMC4 Rabbit Monoclonal Antibody . Tested in WB, IHC, IP applications. This antibody reacts with Human, Mouse, Rat. |
| Gene ID | 51234 |
|---|---|
| Other Names | ER membrane protein complex subunit 4, Cell proliferation-inducing gene 17 protein, Transmembrane protein 85, EMC4, TMEM85 |
| Calculated MW | 18 kDa |
| Application Details | WB 1:500-1:2000 IHC 1:50-1:200 IP 1:50 |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 30E32 |
| Immunogen | A synthesized peptide derived from human EMC4 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | EMC4 |
|---|---|
| Synonyms | TMEM85 |
| Function | Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29242231, PubMed:29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N- terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Could also be a single-pass transmembrane protein with cytosolic N-terminus and lumenal C-terminus. |
| Tissue Location | Isoform 1 is expressed in brain and heart. Isoform 2 is expressed in heart. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 370.00
Cat# ABO16496
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