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MKK3 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IP |
|---|---|
| Primary Accession | P46734 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 39318 Da |
| Gene ID | 5606 |
|---|---|
| Application & Usage | Western blot analysis (0.5-4 µg/ml) and immunoprecipitation. However, the optimal conditions should be determined individually. |
| Other Names | MAPKK3, MEK3, PRKMK3, MAP2K3, MKK3 |
| Target/Specificity | MKK3 |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 100 µg (0.2 mg/ml) protein A affinity purified rabbit anti-MKK3 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | MKK3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MAP2K3 |
|---|---|
| Synonyms | MEK3, MKK3, PRKMK3, SKK2 |
| Function | Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. |
| Tissue Location | Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues |
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Provided below are standard protocols that you may find useful for product applications.
Background
MKK3 is a protein kinase that phosphorylates the p38 MAPK. Phosphorylation by MKK3 occurs on threonine and tyrosine residues and increases the activity of p38 to stimulate transcription factors ATF2 and Elk-1. MKK3, together with MKK6, serves as upstream regulators of p38 MAPK activation. A structural variant, MKK3b, has been identified that contains 29 more amino acids at its N-terminus.
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