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CD6
Mouse Monoclonal antibody(Mab)
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- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P30203 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 585A3B7 |
| Calculated MW | 71801 Da |
| Gene ID | 923 |
|---|---|
| Gene Name | CD6 |
| Other Names | T-cell differentiation antigen CD6, T12, TP120, CD6, Soluble CD6, CD6 (HGNC:1691) |
| Dilution | IHC-P~~Ready-to-use IHC~~Ready-to-use |
| Storage | Maintain refrigerated at 2-8°C |
| Precautions | CD6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CD6 (HGNC:1691) |
|---|---|
| Function | Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806) Colocalizes with the TCR/CD3 complex at the immunological synapse (PubMed:15294938). |
| Tissue Location | Detected on thymocytes (PubMed:15294938). Detected on peripheral blood T-cells (PubMed:15048703, PubMed:16352806). Detected on natural killer (NK) cells (PubMed:16352806). Soluble CD6 is detected in blood serum (at protein level) (PubMed:17601777). Detected in spleen, thymus, appendix, lymph node and peripheral blood leukocytes (PubMed:9013954). Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. |
Research Areas
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
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Cat# AD80406-010
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