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> home > Products > Primary Antibodies > Antibody Collections > Apoptosis signaling > Granzyme B Antibody
Granzyme B Antibody
Mouse Monoclonal Antibody (Mab)
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Application 
| IHC |
|---|---|
| Primary Accession | P10144 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG |
| Clone Names | 974E3A1 |
| Calculated MW | 27716 Da |
| Gene ID | 3002 |
|---|---|
| Gene Name | GZMB |
| Other Names | Granzyme B, 3.4.21.79, C11, CTLA-1, Cathepsin G-like 1, CTSGL1, Cytotoxic T-lymphocyte proteinase 2, Lymphocyte protease, Fragmentin-2, Granzyme-2, Human lymphocyte protein, HLP, SECT, T-cell serine protease 1-3E, GZMB, CGL1, CSPB, CTLA1, GRB |
| Dilution | IHC~~Ready-to-use |
| Storage | Maintain refrigerated at 2-8°C |
| Precautions | Granzyme B Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GZMB {ECO:0000303|PubMed:32188940, ECO:0000312|HGNC:HGNC:4709} |
|---|---|
| Synonyms | CGL1, CSPB, CTLA1, GRB |
| Function | This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. |
| Cellular Location | Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AD80412-010
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