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CD35
Rabbit Monoclonal antibody(Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P17927 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone Names | 463M9T2 |
| Calculated MW | 223663 Da |
| Gene ID | 1378 |
|---|---|
| Gene Name | CR1 |
| Other Names | Complement receptor type 1, C3b/C4b receptor, CD35, CR1, C3BR |
| Dilution | IHC-P~~Ready-to-use IHC~~Ready-to-use |
| Storage | Maintain refrigerated at 2-8°C |
| Precautions | CD35 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CR1 |
|---|---|
| Synonyms | C3BR |
| Function | Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed:2963069). Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation (PubMed:2963069). Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d (PubMed:2972794, PubMed:8175757). Plays also a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells (PubMed:25742728). |
| Cellular Location | Membrane; Single-pass type I membrane protein |
| Tissue Location | Present on erythrocytes, a subset of T cells, mature B cells, follicular dendritic cells, monocytes and granulocytes. |
Research Areas
Citations (0)
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Submit your citation using an Abcepta antibody to
info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AD80421-010
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