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Goat Anti-RAC2 Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | P15153 |
| Other Accession | NP_002863, 5880 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 100ug/200ul |
| Isotype | IgG |
| Calculated MW | 21429 Da |
| Gene ID | 5880 |
|---|---|
| Other Names | Ras-related C3 botulinum toxin substrate 2, GX, Small G protein, p21-Rac2, RAC2 |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-RAC2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RAC2 (HGNC:9802) |
|---|---|
| Function | Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state (PubMed:30723080). In its active state, binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Regulatory subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:1660188). |
| Cellular Location | Cytoplasm. Note=Membrane-associated when activated |
| Tissue Location | Hematopoietic specific. |
- Primary Antibodies
- Cancer
- Cell Biology
- Signal Transduction
- Antibody Collections
- Goat Antibodies
- Anti-Wnt-Pathway (plus Lgr5) Antibodies
- B cell receptor signaling
- Fc gamma R-mediated phagocytosis
- Immune system process
- T cell activation
- Chemokine signaling
- Inflammation mediated by chemokine and cytokine signaling
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.
References
Polymorphisms in innate immunity genes and risk of childhood leukemia. Han S, et al. Hum Immunol, 2010 Jul. PMID 20438785.
Risk of meningioma and common variation in genes related to innate immunity. Rajaraman P, et al. Cancer Epidemiol Biomarkers Prev, 2010 May. PMID 20406964.
Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. Segat L, et al. Vaccine, 2010 Mar 2. PMID 20056178.
Differential regulation of phospholipase C-beta2 activity and membrane interaction by Galphaq, Gbeta1gamma2, and Rac2. Gutman O, et al. J Biol Chem, 2010 Feb 5. PMID 20007712.
Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2. Zhang H, et al. J Immunol, 2009 Aug 15. PMID 19625648.
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