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RAC2 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | P15153 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 21429 Da |
| Gene ID | 5880 |
|---|---|
| Other Names | Ras-related C3 botulinum toxin substrate 2, GX, Small G protein, p21-Rac2, RAC2 |
| Target/Specificity | This RAC2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 178-192 amino acids from the C-terminal region of human RAC2. |
| Dilution | IF~~1:25 WB~~1:2000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RAC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RAC2 (HGNC:9802) |
|---|---|
| Function | Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state (PubMed:30723080). In its active state, binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Regulatory subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:1660188). |
| Cellular Location | Cytoplasm. Note=Membrane-associated when activated |
| Tissue Location | Hematopoietic specific. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.
References
Didsbury J.,et al.J. Biol. Chem. 264:16378-16382(1989).
Puhl H.L. III,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Dunham I.,et al.Nature 402:489-495(1999).
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