Goat Anti-TFEC Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | O14948 |
Other Accession | NP_001018068, 22797 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Concentration | 100ug/200ul |
Isotype | IgG |
Calculated MW | 38788 Da |
Gene ID | 22797 |
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Other Names | Transcription factor EC, TFE-C, Class E basic helix-loop-helix protein 34, bHLHe34, Transcription factor EC-like, hTFEC-L, TFEC, BHLHE34, TCFEC, TFECL |
Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Goat Anti-TFEC Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TFEC |
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Synonyms | BHLHE34, TCFEC, TFECL |
Function | Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form. |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:11467950} |
Tissue Location | Expressed moderately in spleen, kidney, bone marrow, small intestine and leukocytes. Expressed weakly in testis, trachea and colon. |
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Provided below are standard protocols that you may find useful for product applications.
References
The DNA sequence of human chromosome 7. Hillier LW, et al. Nature, 2003 Jul 10. PMID 12853948.
Human chromosome 7: DNA sequence and biology. Scherer SW, et al. Science, 2003 May 2. PMID 12690205.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter. Mansky KC, et al. J Leukoc Biol, 2002 Feb. PMID 11818452.
TFEC can function as a transcriptional activator of the nonmuscle myosin II heavy chain-A gene in transfected cells. Chung MC, et al. Biochemistry, 2001 Jul 31. PMID 11467950.
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