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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > ARIH2 / TRIAD1 Antibody (C-Term)
ARIH2 / TRIAD1 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, IP, E |
|---|---|
| Primary Accession | O95376 |
| Other Accession | NP_006312.1, 10425, 23807 (mouse) |
| Reactivity | Human, Mouse |
| Predicted | Rat, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 57819 Da |
| Gene ID | 10425 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase ARIH2, ARI-2, Protein ariadne-2 homolog, 6.3.2.-, Triad1 protein, ARIH2, ARI2, TRIAD1 |
| Dilution | WB~~1:1000 IF~~1:50~200 IP~~N/A E~~N/A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ARIH2 / TRIAD1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ARIH2 {ECO:0000303|PubMed:31253590, ECO:0000312|HGNC:HGNC:690} |
|---|---|
| Function | E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655, PubMed:33268465, PubMed:34518685, PubMed:38418882). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (PubMed:33268465, PubMed:34518685, PubMed:38418882). The initial ubiquitin is then elongated (PubMed:33268465). E3 ubiquitin- protein ligase activity is activated upon binding to neddylated form of the cullin-5 (CUL5) component of the ECS complex (PubMed:24076655). Together with the ECS(ASB9) complex, catalyzes ubiquitination of CKB (PubMed:33268465). Promotes ubiquitination of DCUN1D1 (PubMed:30587576). Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006). |
| Cellular Location | Nucleus. Cytoplasm |
| Tissue Location | Widely expressed with higher expression in granulocytes. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
TRIADs: a new class of proteins with a novel cysteine-rich signature. van der Reijden BA, Erpelinck-Verschueren CA, Lowenberg B, Jansen JH. Protein Sci. 1999 Jul;8(7):1557-61. PMID: 10422847
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$ 423.00
Cat# AF2311a
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