Rhophilin 2 (Internal) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC, E |
---|---|
Primary Accession | Q8IUC4 |
Other Accession | NP_149094.3, 85415 |
Reactivity | Human |
Predicted | Mouse, Rat, Cow |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 76993 Da |
Gene ID | 85415 |
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Other Names | Rhophilin-2, 76 kDa RhoB effector protein, GTP-Rho-binding protein 2, p76RBE, RHPN2 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Rhophilin 2 (Internal) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RHPN2 |
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Function | Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. |
Cellular Location | Cytoplasm, perinuclear region |
Tissue Location | Widely expressed. Highly expressed in prostate, trachea, stomach, colon, thyroid and pancreas. Expressed at lower level in brain, spinal cord, kidney, placenta and liver |
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Provided below are standard protocols that you may find useful for product applications.
References
The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization. Peck JW, Oberst M, Bouker KB, Bowden E, Burbelo PD. J Biol Chem. 2002 Nov 15;277(46):43924-32. PMID: 12221077
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