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Rhophilin 2 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q8IUC4 |
| Reactivity | Rat, Pig, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 77 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Rhophilin 2 |
| Epitope Specificity | 601-686/686 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasm > perinuclear region. |
| SIMILARITY | Belongs to the RHPN family. Contains 1 BRO1 domain. Contains 1 PDZ (DHR) domain. Contains 1 REM (Hr1) repeat. |
| SUBUNIT | Interacts with GTP-bound RhoA and RhoB. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins. The encoded protein binds both GTP- and GDP-bound RhoA and GTP-bound RhoB and may be involved in the organization of the actin cytoskeleton. [provided by RefSeq, Apr 2009] |
| Gene ID | 85415 |
|---|---|
| Other Names | Rhophilin-2, 76 kDa RhoB effector protein, GTP-Rho-binding protein 2, p76RBE, RHPN2 |
| Target/Specificity | Widely expressed. Highly expressed in prostate, trachea, stomach, colon, thyroid and pancreas. Expressed at lower level in brain, spinal cord, kidney, placenta and liver. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | RHPN2 |
|---|---|
| Function | Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. |
| Cellular Location | Cytoplasm, perinuclear region |
| Tissue Location | Widely expressed. Highly expressed in prostate, trachea, stomach, colon, thyroid and pancreas. Expressed at lower level in brain, spinal cord, kidney, placenta and liver |
Research Areas
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Application Protocols
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$ 385.00
Cat# AP57697
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