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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > INDO / IDO Antibody (internal region)
INDO / IDO Antibody (internal region)
Peptide-affinity purified goat antibody
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Application 
| IHC, E |
|---|---|
| Primary Accession | P14902 |
| Other Accession | NP_002155.1, 3620 |
| Predicted | Human, Mouse, Rat, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 45326 Da |
| Gene ID | 3620 |
|---|---|
| Other Names | Indoleamine 2, 3-dioxygenase 1, IDO-1, 1.13.11.52, Indoleamine-pyrrole 2, 3-dioxygenase, IDO1, IDO, INDO |
| Dilution | IHC~~1:100~500 E~~N/A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | INDO / IDO Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IDO1 (HGNC:6059) |
|---|---|
| Synonyms | IDO, INDO |
| Function | Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a suppressor of anti-tumor immunity (PubMed:14502282, PubMed:23103127, PubMed:25157255, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885). Protects the fetus from maternal immune rejection (PubMed:25691885). |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:P28776, ECO:0000303|PubMed:25691885} |
| Tissue Location | Expressed in mature dendritic cells located in lymphoid organs (including lymph nodes, spleen, tonsils, Peyers's patches, the gut lamina propria, and the thymic medulla), in some epithelial cells of the female genital tract, as well as in endothelial cells of term placenta and in lung parenchyma (PubMed:25691885). Weakly or not expressed in most normal tissues, but mostly inducible in most tissues (PubMed:25691885). Expressed in more than 50% of tumors, either by tumoral, stromal, or endothelial cells (expression in tumor is associated with a worse clinical outcome) (PubMed:18418598). Not overexpressed in tumor-draining lymph nodes (PubMed:25691885, PubMed:26155395). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Munn DH, Sharma MD, Baban B, Harding HP, Zhang Y, Ron D, Mellor AL. Immunity. 2005 May;22(5):633-42. PMID: 15894280
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$ 423.00
Cat# AF2460a
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