CHD5 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IF, FC, Pep-ELISA |
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Primary Accession | Q8TDI0 |
Other Accession | NP_056372.1, 26038, 269610 (mouse) |
Predicted | Human, Mouse, Rat, Dog |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 223050 Da |
Gene ID | 26038 |
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Other Names | Chromodomain-helicase-DNA-binding protein 5, CHD-5, 3.6.4.12, ATP-dependent helicase CHD5, CHD5 {ECO:0000312|EMBL:AAL98962.1}, KIAA0444 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CHD5 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CHD5 {ECO:0000312|EMBL:AAL98962.1} |
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Synonyms | KIAA0444 |
Function | Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. |
Cellular Location | Nucleus. Chromosome {ECO:0000250|UniProtKB:A2A8L1} |
Tissue Location | Preferentially expressed in total brain, fetal brain, and cerebellum. It is also moderately expressed in the adrenal gland and detected in testis. |
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Provided below are standard protocols that you may find useful for product applications.
References
CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system. Thompson PM, Gotoh T, Kok M, White PS, Brodeur GM. Oncogene. 2003 Feb 20;22(7):1002-11. PMID: 12592387 [PubMed - indexed for MEDLINE
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