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EPB41L4B / EHM2 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, E |
|---|---|
| Primary Accession | Q9H329 |
| Other Accession | NP_060894.2, NP_061987.3, 54566 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 99712 Da |
| Gene ID | 54566 |
|---|---|
| Other Names | Band 4.1-like protein 4B, FERM-containing protein CG1, Protein EHM2, EPB41L4B, EHM2 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | EPB41L4B / EHM2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EPB41L4B (HGNC:19818) |
|---|---|
| Function | Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing (PubMed:23664528). May have a role in mediating cytoskeletal changes associated with steroid- induced cell differentiation (PubMed:14521927). |
| Cellular Location | Cytoplasm. Cell junction, tight junction Note=Accumulates along apical cell-cell boundaries and is also detected in the cytoplasm in a punctate manner. |
| Tissue Location | Expressed at higher levels in acute wounds than chronic wounds with increased expression in healing wounds, especially at the leading wound edge (PubMed:23664528). Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in testis with lower levels in prostate and breast (PubMed:14521927) |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognise both reported isoforms (NP_060894.2; NP_061987.3).
References
Protein 4.1, a component of the erythrocyte membrane skeleton and its related homologue proteins forming the protein 4.1/FERM superfamily. Diakowski W, Grzybek M, Sikorski AF. Folia Histochem Cytobiol. 2006;44(4):231-48. Review. PMID: 17219717
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