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PTPRM Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, E |
|---|---|
| Primary Accession | P28827 |
| Other Accession | NP_001098714.1, NP_002836.3, 5797 |
| Predicted | Human, Mouse, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 163682 Da |
| Gene ID | 5797 |
|---|---|
| Other Names | Receptor-type tyrosine-protein phosphatase mu, Protein-tyrosine phosphatase mu, R-PTP-mu, 3.1.3.48, PTPRM, PTPRL1 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PTPRM Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PTPRM |
|---|---|
| Synonyms | PTPRL1 |
| Function | Receptor protein-tyrosine phosphatase that mediates homotypic cell-cell interactions and plays a role in adipogenic differentiation via modulation of p120 catenin/CTNND1 phosphorylation (PubMed:10753936, PubMed:17761881). Promotes CTNND1 dephosphorylation and prevents its cytoplasmic localization where it inhibits SLC2A4 membrane trafficking. In turn, SLC2A4 is directed to the plasma membrane and performs its glucose transporter function (PubMed:21998202). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Note=Localizes in regions of cell- cell contact. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognise both reported isoforms (NP_001098714.1 and NP_002836.3).
References
Molecular analysis of receptor protein tyrosine phosphatase mu-mediated cell adhesion. Aricescu AR, Hon WC, Siebold C, Lu W, van der Merwe PA, Jones EY. EMBO J. 2006 Feb 22;25(4):701-12. Epub 2006 Feb 2. PMID: 16456543
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