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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Palladin (aa895-907) Antibody (internal region)
Palladin (aa895-907) Antibody (internal region)
Peptide-affinity purified goat antibody
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Application 
| WB, E |
|---|---|
| Primary Accession | Q8WX93 |
| Other Accession | NP_057165.3, 23022, 72333 (mouse), 364558 (rat) |
| Reactivity | Human |
| Predicted | Mouse, Rat, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 150564 Da |
| Gene ID | 23022 |
|---|---|
| Other Names | Palladin, SIH002, Sarcoma antigen NY-SAR-77, PALLD, KIAA0992 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Palladin (aa895-907) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PALLD |
|---|---|
| Synonyms | KIAA0992 |
| Function | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. |
| Cellular Location | Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cytoplasm, myofibril, sarcomere, Z line. Cell projection, ruffle. Cell projection, podosome {ECO:0000250|UniProtKB:P0C5E3}. Cell projection, lamellipodium. Cell projection, axon {ECO:0000250|UniProtKB:P0C5E3}. Cell projection, growth cone {ECO:0000250|UniProtKB:P0C5E3}. Note=Localizes to stress fibers and Z lines (PubMed:11598191, PubMed:16125169, PubMed:17322171, PubMed:17537434). Preferentially expressed in the excitatory presynaptic terminals (By similarity). {ECO:0000250|UniProtKB:P0C5E3, ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:16125169, ECO:0000269|PubMed:17322171, ECO:0000269|PubMed:17537434} |
| Tissue Location | Detected in both muscle and non-muscle tissues. High expression in prostate, ovary, colon, and kidney. Not detected in spleen, skeletal muscle, lung and peripheral blood lymphocytes (at protein level). Protein is overexpressed in FA6, HPAF, IMIM-PC2, SUIT-2 and PancTu-II sporadic pancreatic cancer cell lines |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Five common gene variants identify elevated genetic risk for coronary heart disease. Bare LA, Morrison AC, Rowland CM, Shiffman D, Luke MM, Iakoubova OA, Kane JP, Malloy MJ, Ellis SG, Pankow JS, Willerson JT, Devlin JJ, Boerwinkle E. Genet. Med. 2007 Oct 9 (10): 682-9. PMID: 18073581
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$ 423.00
Cat# AF2875a
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