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FBXO32 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, Pep-ELISA |
|---|---|
| Primary Accession | Q969P5 |
| Other Accession | NP_478136.1, 114907, 67731 (mouse), 171043 (rat) |
| Reactivity | Human, Mouse |
| Predicted | Rat, Pig, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 41637 Da |
| Gene ID | 114907 |
|---|---|
| Other Names | F-box only protein 32, Atrogin-1, Muscle atrophy F-box protein, MAFbx, FBXO32 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FBXO32 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FBXO32 |
|---|---|
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. |
| Cellular Location | Cytoplasm. Nucleus Note=Shuttles between cytoplasm and the nucleus |
| Tissue Location | Specifically expressed in cardiac and skeletal muscle |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize reported isoform 1 (NP_478136.1).
References
The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity. Hanai J, Cao P, Tanksale P, Imamura S, Koshimizu E, Zhao J, Kishi S, Yamashita M, Phillips PS, Sukhatme VP, Lecker SH. J Clin Invest. 2007 Dec;117(12):3940-51. PMID: 17992259
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