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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > SPARTIN Antibody (internal region)
SPARTIN Antibody (internal region)
Peptide-affinity purified goat antibody
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Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q8N0X7 |
| Other Accession | NP_055902.1, 23111 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 72833 Da |
| Gene ID | 23111 |
|---|---|
| Other Names | Spartin, Spastic paraplegia 20 protein, Trans-activated by hepatitis C virus core protein 1, SPG20, KIAA0610, TAHCCP1 |
| Dilution | WB~~1:1000 IF~~1:50~200 E~~N/A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SPARTIN Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SPART (HGNC:18514) |
|---|---|
| Function | Lipophagy receptor that plays an important role in lipid droplet (LD) turnover in motor neurons (PubMed:37443287). Localizes to LDs and interacts with components of the autophagy machinery, such as MAP1LC3A/C proteins to deliver LDs to autophagosomes for degradation via lipophagy (PubMed:37443287). Lipid transfer protein required for lipid droplet degradation, including by lipophagy (PubMed:38190532). Can bind and transfer all lipid species found in lipid droplets, from phospholipids to triglycerides and sterol esters but the direction of lipid transfer by spartin and its cargos are unknown (PubMed:38190532). May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis (PubMed:20719964). |
| Cellular Location | Cytoplasm. Midbody. Lipid droplet Note=Transiently associated with endosomes (PubMed:19580544) Colocalized with IST1 to the ends of Flemming bodies during cytokinesis (PubMed:20719964). |
| Tissue Location | Ubiquitously expressed, with highest levels of expression detected in adipose tissue |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
The hereditary spastic paraplegia protein spartin localises to mitochondria Lu J, Rashid F, Byrne PC. J Neurochem. 2006 Sep;98(6):1908-19. PMID: 16945107
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$ 423.00
Cat# AF2902a
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