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Glutamate Dehydrogenase Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IF, E |
|---|---|
| Primary Accession | P00367 |
| Other Accession | NP_005262.1, NP_036216.2, 2746, 2747, 14661 (mouse), 24399 (rat) |
| Reactivity | Human, Mouse |
| Predicted | Rat, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 61398 Da |
| Gene ID | 2746 |
|---|---|
| Other Names | Glutamate dehydrogenase 1, mitochondrial, GDH 1, 1.4.1.3, GLUD1, GLUD |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Glutamate Dehydrogenase Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GLUD1 |
|---|---|
| Synonyms | GLUD |
| Function | Mitochondrial glutamate dehydrogenase that catalyzes the conversion of L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:11032875, PubMed:11254391, PubMed:16023112, PubMed:16959573). Plays a role in insulin homeostasis (PubMed:11297618, PubMed:9571255). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). |
| Cellular Location | Mitochondrion. Endoplasmic reticulum. Note=Mostly translocates into the mitochondria, only a small amount of the protein localizes to the endoplasmic reticulum. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize both reported isoforms (NP_005262.1; NP_036216.2).
References
Expression of enzymes regulating
placental ammonia homeostasis in human fetal growth restricted pregnancies. Jozwik M, Pietrzycki B, Jozwik M, Anthony RV. Placenta. 2009 Jul;30(7):607-12. PMID: 19500843
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