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FBXO4 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q9UKT5 |
| Other Accession | NP_036308.1, NP_277019.1, 26272, 106052 (mouse), 310363 (rat) |
| Predicted | Human, Mouse, Rat |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 44136 Da |
| Gene ID | 26272 |
|---|---|
| Other Names | F-box only protein 4, FBXO4, FBX4 |
| Dilution | E~~N/A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FBXO4 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FBXO4 |
|---|---|
| Synonyms | FBX4 |
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10531035, PubMed:18598945, PubMed:20181953, PubMed:29142209). Promotes ubiquitination of cyclin-D1 (CCND1) and its subsequent proteasomal degradation (PubMed:18598945). However, it does not act as a major regulator of CCND1 stability during the G1/S transition (By similarity). Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (PubMed:16275645, PubMed:20159592). Promotes ubiquitination of FXR1 following phosphorylation of FXR1 by GSK3B, leading to FXR1 degradation by the proteasome (PubMed:29142209). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q8CHQ0}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize isoform 1 and 2 (NP_036308.1; NP_277019.1).
References
Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer. Barbash O, Zamfirova P, Lin DI, Chen X, Yang K, Nakagawa H, Lu F, Rustgi AK, Diehl JA, Cancer cell 2008 Jul 14 (1): 68-78. PMID: 18598945
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