LARGE (aa421-433) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, E |
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Primary Accession | O95461 |
Other Accession | NP_004728.1, 9215 |
Reactivity | Human |
Predicted | Dog |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 88066 Da |
Gene ID | 9215 |
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Other Names | Glycosyltransferase-like protein LARGE1, 2.4.-.-, Acetylglucosaminyltransferase-like 1A, Xylosyltransferase LARGE, 2.4.2.-, Beta-1, 3-glucuronyltransferase LARGE, 2.4.1.-, LARGE, KIAA0609, LARGE1 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | LARGE (aa421-433) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | LARGE1 (HGNC:6511) |
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Synonyms | KIAA0609, LARGE |
Function | Bifunctional glycosyltransferase with both alpha-1,3- xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain- containing extracellular proteins with high affinity (PubMed:15661757, PubMed:15752776, PubMed:21987822, PubMed:22223806, PubMed:23125099, PubMed:25279697, PubMed:25279699). Elongates the glucuronyl-beta-1,4- xylose-beta disaccharide primer structure initiated by B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:22223806, PubMed:23125099, PubMed:25138275, PubMed:25279697, PubMed:25279699, PubMed:32975514). Requires the phosphorylation of core M3 (O-mannosyl trisaccharide) by POMK to elongate the glucuronyl-beta-1,4-xylose-beta disaccharide primer (PubMed:21987822). Plays a key role in skeletal muscle function and regeneration (By similarity). |
Cellular Location | Golgi apparatus membrane; Single-pass type II membrane protein |
Tissue Location | Ubiquitous. Highest expression in heart, brain and skeletal muscle. |

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Provided below are standard protocols that you may find useful for product applications.
Background
Reported variants represent identical protein: NP_004728.1, NP_598397.1
References
Loss of alpha-dystroglycan laminin binding in epithelium-derived cancers is caused by silencing of LARGE. de Bernabé DB, Inamori K, Yoshida-Moriguchi T, Weydert CJ, Harper HA, Willer T, Henry MD, Campbell KP, The Journal of biological chemistry 2009 Apr 284 (17): 11279-84. PMID: 19244252

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