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MCF2L Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O15068 |
| Other Accession | NP_001106203.1, NP_079255.3, 23263, 17207 (mouse), 117020 (rat) |
| Reactivity | Human |
| Predicted | Mouse, Rat, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 128109 Da |
| Gene ID | 23263 |
|---|---|
| Other Names | Guanine nucleotide exchange factor DBS, DBL's big sister, MCF2-transforming sequence-like protein, MCF2L, KIAA0362 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MCF2L Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MCF2L |
|---|---|
| Synonyms | KIAA0362, OST {ECO:0000303|PubMed:151576 |
| Function | Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 (PubMed:15157669). |
| Cellular Location | [Isoform 5]: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm {ECO:0000250|UniProtKB:Q64096}. Cell membrane {ECO:0000250|UniProtKB:Q64096}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64096}; Cytoplasmic side {ECO:0000250|UniProtKB:Q64096} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize both reported isoforms (NP_001106203.1; NP_079255.3).
References
Mutation of ARHGAP9 in patients with coronary spastic angina. Takefuji M, Asano H, Mori K, Amano M, Kato K, Watanabe T, Morita Y, Katsumi A, Itoh T, Takenawa T, Hirashiki A, Izawa H, Nagata K, Hirayama H, Takatsu F, Naoe T, Yokota M, Kaibuchi K, Journal of human genetics 2010 Jan 55 (1): 42-9. PMID: 19911011
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