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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > ZDHHC1 (aa174-182) Antibody (internal region)
ZDHHC1 (aa174-182) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q8WTX9 |
| Other Accession | NP_037436.1, 29800, 70796 (mouse), 291967 (rat) |
| Predicted | Human, Mouse, Rat |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 54818 Da |
| Gene ID | 29800 |
|---|---|
| Other Names | Probable palmitoyltransferase ZDHHC1, 2.3.1.225, DHHC domain-containing cysteine-rich protein 1, Zinc finger DHHC domain-containing protein 1, DHHC-1, Zinc finger protein 377, ZDHHC1, C16orf1, ZNF377 |
| Dilution | E~~N/A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZDHHC1 (aa174-182) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZDHHC1 {ECO:0000303|PubMed:39173637, ECO:0000312|HGNC:HGNC:17916} |
|---|---|
| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as NCDN and NLRP3 (PubMed:39173637). Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation (By similarity). Acts as an activator of the NLRP3 inflammasome by mediating palmitoylation of 'Cys-130' and 'Cys-958' of NLRP3, thereby promoting NLRP3 phosphorylation and activation by NEK7 (PubMed:39173637). |
| Cellular Location | Endosome membrane {ECO:0000250|UniProtKB:Q8R0N9}; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus |
| Tissue Location | Widely expressed with significant expression in heart, brain, placenta, lung, liver, kidney, testis, thymus and small intestine (PubMed:16647879). Expressed at lower levels in adult pancreas and lung (PubMed:10395086). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
The DHHC domain: a new highly conserved cysteine-rich motif. Putilina T, Wong P, Gentleman S, Molecular and cellular biochemistry 1999 May 195 (1-2): 219-26. PMID: 10395086
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$ 255.00
Cat# AF3353a
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