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ZDHHC1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8WTX9 |
| Other Accession | Q8R0N9, NP_037436.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 54818 Da |
| Antigen Region | 14-43 aa |
| Gene ID | 29800 |
|---|---|
| Other Names | Probable palmitoyltransferase ZDHHC1, DHHC domain-containing cysteine-rich protein 1, Zinc finger DHHC domain-containing protein 1, DHHC-1, Zinc finger protein 377, ZDHHC1, C16orf1, ZNF377 |
| Target/Specificity | This ZDHHC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-43 amino acids from the N-terminal region of human ZDHHC1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZDHHC1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZDHHC1 {ECO:0000303|PubMed:39173637, ECO:0000312|HGNC:HGNC:17916} |
|---|---|
| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as NCDN and NLRP3 (PubMed:39173637). Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation (By similarity). Acts as an activator of the NLRP3 inflammasome by mediating palmitoylation of 'Cys-130' and 'Cys-958' of NLRP3, thereby promoting NLRP3 phosphorylation and activation by NEK7 (PubMed:39173637). |
| Cellular Location | Endosome membrane {ECO:0000250|UniProtKB:Q8R0N9}; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus |
| Tissue Location | Widely expressed with significant expression in heart, brain, placenta, lung, liver, kidney, testis, thymus and small intestine (PubMed:16647879). Expressed at lower levels in adult pancreas and lung (PubMed:10395086). |
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Feng, T., et al. Hum. Genet. 128(3):269-280(2010)
Putilina, T., et al. Mol. Cell. Biochem. 195 (1-2), 219-226 (1999) :
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$ 150.00
$ 385.00
Cat# AP10315a
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