UGT8 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q16880 |
Other Accession | NP_003351.2, 7368, 50555 (rat) |
Predicted | Human, Rat, Dog, Cow |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 61438 Da |
Gene ID | 7368 |
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Other Names | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase, 2.4.1.45, Ceramide UDP-galactosyltransferase, Cerebroside synthase, UDP-galactose-ceramide galactosyltransferase, UGT8, CGT, UGT4 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | UGT8 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | UGT8 (HGNC:12555) |
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Synonyms | CGT, UGT4 |
Function | Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system (PubMed:9125199). Galactosylates both hydroxy- and non-hydroxy fatty acid-containing ceramides and diglycerides (By similarity). |
Cellular Location | Membrane; Single-pass membrane protein. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q09426} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Reported variants represent identical protein: NP_001121646.1, NP_003351.2.
References
A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J, Edenberg H, Kramer J, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP, Human molecular genetics 2010 Jun 19 (12): 2497-506. PMID: 20332099
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