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Synaptotagmin-2 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8N9I0 |
| Other Accession | NP_796376.2, 127833, 20980 (mouse), 24805 (rat) |
| Reactivity | Mouse |
| Predicted | Human, Rat |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 46872 Da |
| Gene ID | 127833 |
|---|---|
| Other Names | Synaptotagmin-2, Synaptotagmin II, SytII, SYT2 |
| Dilution | WB~~1:1000 E~~N/A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Synaptotagmin-2 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SYT2 (HGNC:11510) |
|---|---|
| Function | Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P29101}; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000250|UniProtKB:P29101}. Cytoplasm {ECO:0000250|UniProtKB:P29101} |
| Tissue Location | Expressed at the neuromuscular junction (PubMed:33659639). Expressed in melanocytes (PubMed:23999003) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Reported variants represent identical protein: NP_001129976.1, NP_796376.2
References
Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensor. Young SM, Neher E, Neuron 2009 Aug 63 (4): 482-96. PMID: 19709630
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