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SYT2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant SYT2.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8N9I0 |
| Other Accession | NM_177402 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 1G10 |
| Calculated MW | 46872 Da |
| Gene ID | 127833 |
|---|---|
| Other Names | Synaptotagmin-2, Synaptotagmin II, SytII, SYT2 |
| Target/Specificity | SYT2 (NP_796376, 311 a.a. ~ 418 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SYT2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (Hilbush and Morgan, 1994 [PubMed 8058779]).
References
Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensor. Young SM Jr, et al. Neuron, 2009 Aug 27. PMID 19709630.Human SCAMP5, a novel secretory carrier membrane protein, facilitates calcium-triggered cytokine secretion by interaction with SNARE machinery. Han C, et al. J Immunol, 2009 Mar 1. PMID 19234194.Zea mays annexins modulate cytosolic free Ca2+ and generate a Ca2+-permeable conductance. Laohavisit A, et al. Plant Cell, 2009 Feb. PMID 19234085.Dominant antigenic peptides located at the heavy chain terminal of botulinum neurotoxin B contain receptor-binding sites for synaptotagmin II. Shi J, et al. Biochem Biophys Res Commun, 2008 Sep 19. PMID 18639519.Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.
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