SLC6A3 / DAT Antibody (internal region, near N-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q01959 |
Other Accession | NP_001035.1, 6531 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 68495 Da |
Gene ID | 6531 |
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Other Names | Sodium-dependent dopamine transporter, DA transporter, DAT, Solute carrier family 6 member 3, SLC6A3, DAT1 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SLC6A3 / DAT Antibody (internal region, near N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SLC6A3 |
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Synonyms | DAT1 |
Function | Mediates sodium- and chloride-dependent transport of dopamine (PubMed:1406597, PubMed:8302271, PubMed:10375632, PubMed:11093780, PubMed:15505207, PubMed:19478460). Also mediates sodium- and chloride- dependent transport of norepinephrine (also known as noradrenaline) (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Cell projection, neuron projection {ECO:0000250|UniProtKB:P23977}. Cell projection, axon. Note=Localizes to neurite tips in neuronal cells (By similarity). Colocalizes with SEPTIN4 at axon terminals, especially at the varicosities (By similarity) {ECO:0000250|UniProtKB:P23977, ECO:0000250|UniProtKB:Q61327} |
Tissue Location | Highly expressed in substantia nigra (PubMed:7637582). Expressed in axonal varicosities in dopaminergic nerve terminals (at protein level) (PubMed:17296554). Expressed in the striatum (at protein level) (PubMed:17296554) |
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Provided below are standard protocols that you may find useful for product applications.
References
Relationship of DAT1 and adult ADHD to task-positive and task-negative working memory networks. Brown AB, Biederman J, Valera E, Makris N, Doyle A, Whitfield-Gabrieli S, Mick E, Spencer T, Faraone S, Seidman L. Psychiatry Res. 2011 Jul 30;193(1):7-16. Epub 2011 May 18. PMID: 21596533
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