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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > complement component 7 Antibody (internal region)
complement component 7 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
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Application 
| WB, E |
|---|---|
| Primary Accession | P10643 |
| Other Accession | NP_000578.2, 730 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 93518 Da |
| Gene ID | 730 |
|---|---|
| Other Names | Complement component C7, C7 |
| Dilution | WB~~1:1000 E~~N/A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | complement component 7 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | C7 {ECO:0000303|PubMed:3335508, ECO:0000312|HGNC:HGNC:1346} |
|---|---|
| Function | Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:22832194, PubMed:26841837, PubMed:27052168, PubMed:30552328, PubMed:3335508). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (PubMed:22832194, PubMed:30552328, PubMed:3335508). The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:22832194, PubMed:30552328, PubMed:3335508). C7 serves as a membrane anchor (PubMed:30552328). During MAC assembly, associates with C5b and C6 to form the C5b-7 complex, a key lipophilic precursor of the MAC complex, which associates with the outer leaflet and reduces the energy for membrane bending (PubMed:30552328, PubMed:32569291). |
| Cellular Location | Secreted. Target cell membrane Note=Secreted as soluble protein (PubMed:3335508). Inserts into the cell membrane of target cells (PubMed:30552328, PubMed:31061395) |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS. Kallio SP et al. Hum Mol Genet. 2009 May 1;18(9):1670-83. PMID: 19221116
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$ 423.00
Cat# AF4023a
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