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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat anti-TXNDC1 / TMX, biotinylated Antibody
Goat anti-TXNDC1 / TMX, biotinylated Antibody
Peptide-affinity purified goat antibody
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- BACKGROUND
Application 
| WB, Pep-ELISA |
|---|---|
| Primary Accession | Q9H3N1 |
| Other Accession | NP_110382.3 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | TMX1 |
| Calculated MW | 31791 Da |
| Gene ID | 81542 |
|---|---|
| Other Names | TMX1; thioredoxin-related transmembrane protein 1; PDIA11; TMX; TXNDC; TXNDC1; protein disulfide isomerase family A, member 11; thioredoxin domain containing 1; thioredoxin domain-containing protein 1; transmembrane Trx-related protein |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-TXNDC1 / TMX, biotinylated Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TMX1 {ECO:0000303|PubMed:37648867, ECO:0000312|HGNC:HGNC:15487} |
|---|---|
| Function | Thiredoxin domain-containing protein that participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions (PubMed:11152479, PubMed:37648867). Acts as a key inhibitor of the alternative triglyceride biosynthesis pathway by inhibiting the activity of TMEM68/DIESL at the endoplasmic reticulum, thereby restricting accumulation of triacylglycerol (PubMed:37648867). The alternative triglyceride biosynthesis pathway mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids (PubMed:37648867). Acts as a protein disulfide isomerase by catalyzing formation or reduction of disulfide bonds (PubMed:22228764, PubMed:29932915). Specifically mediates formation of disulfide bonds of transmembrane proteins at the endoplasmic reticulum membrane (PubMed:22228764). Involved in endoplasmic reticulum-associated degradation (ERAD) via its protein disulfide isomerase activity by acting on folding-defective polypeptides at the endoplasmic reticulum membrane (PubMed:29932915). Acts as a negative regulator of platelet aggregation following secretion in the extracellular space (PubMed:30425049). Acts as a regulator of endoplasmic reticulum- mitochondria contact sites via its ability to regulate redox signals (PubMed:27502484, PubMed:31304984). Regulates endoplasmic reticulum- mitochondria Ca(2+) flux (PubMed:27502484). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein. Mitochondrion membrane; Single-pass type I membrane protein. Secreted. Note=Predominantly found in the endoplasmic reticulum (PubMed:11152479). Secreted in the extracellular space following thrombin stimulation (PubMed:30425049). Localizes to mitochondria-associated endoplasmic reticulum membrane (MAM); palmitoylation is required for MAM localization (PubMed:22045338, PubMed:27502484, PubMed:31304984). |
| Tissue Location | Ubiquitous (PubMed:11152479). Highly expressed in kidney, liver, placenta and lung (PubMed:11152479) |
Research Areas
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$ 423.00
Cat# AF4350a
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