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TMX1 antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9H3N1 |
| Other Accession | NM_030755, NP_110382 |
| Reactivity | Human, Pig, Horse, Bovine, Dog |
| Predicted | Human, Horse, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 31kDa |
| Gene ID | 81542 |
|---|---|
| Alias Symbol | DKFZp564E1962, PDIA11, TMX, TXNDC, TXNDC1 |
| Other Names | Thioredoxin-related transmembrane protein 1, Thioredoxin domain-containing protein 1, Transmembrane Trx-related protein, TMX1, TMX, TXNDC, TXNDC1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-TMX1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | TMX1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TMX1 {ECO:0000303|PubMed:37648867, ECO:0000312|HGNC:HGNC:15487} |
|---|---|
| Function | Thiredoxin domain-containing protein that participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions (PubMed:11152479, PubMed:37648867). Acts as a key inhibitor of the alternative triglyceride biosynthesis pathway by inhibiting the activity of TMEM68/DIESL at the endoplasmic reticulum, thereby restricting accumulation of triacylglycerol (PubMed:37648867). The alternative triglyceride biosynthesis pathway mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids (PubMed:37648867). Acts as a protein disulfide isomerase by catalyzing formation or reduction of disulfide bonds (PubMed:22228764, PubMed:29932915). Specifically mediates formation of disulfide bonds of transmembrane proteins at the endoplasmic reticulum membrane (PubMed:22228764). Involved in endoplasmic reticulum-associated degradation (ERAD) via its protein disulfide isomerase activity by acting on folding-defective polypeptides at the endoplasmic reticulum membrane (PubMed:29932915). Acts as a negative regulator of platelet aggregation following secretion in the extracellular space (PubMed:30425049). Acts as a regulator of endoplasmic reticulum- mitochondria contact sites via its ability to regulate redox signals (PubMed:27502484, PubMed:31304984). Regulates endoplasmic reticulum- mitochondria Ca(2+) flux (PubMed:27502484). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein. Mitochondrion membrane; Single-pass type I membrane protein. Secreted. Note=Predominantly found in the endoplasmic reticulum (PubMed:11152479). Secreted in the extracellular space following thrombin stimulation (PubMed:30425049). Localizes to mitochondria-associated endoplasmic reticulum membrane (MAM); palmitoylation is required for MAM localization (PubMed:22045338, PubMed:27502484, PubMed:31304984). |
| Tissue Location | Ubiquitous (PubMed:11152479). Highly expressed in kidney, liver, placenta and lung (PubMed:11152479) |
Research Areas
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Matsuo Y.,et al.J. Biol. Chem. 276:10032-10038(2001).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Otsuki T.,et al.DNA Res. 12:117-126(2005).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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$ 389.00
Cat# AI14893
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