Goat anti-CBX5 / HP1-Alpha, biotinylated Antibody
Peptide-affinity purified goat antibody
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- BACKGROUND
Application
| WB, Pep-ELISA |
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Primary Accession | P45973 |
Other Accession | NP_036249.1 |
Reactivity | Human, Mouse, Dog |
Host | Goat |
Clonality | Polyclonal |
Clone Names | CBX5 |
Calculated MW | 22225 Da |
Gene ID | 23468 |
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Other Names | CBX5; chromobox homolog 5; HEL25; HP1; HP1A; HP1 alpha homolog; HP1-ALPHA; HP1Hs alpha; antigen p25; chromobox homolog 5 (HP1 alpha homolog, Drosophila); epididymis luminal protein 25; heterochromatin protein 1 homolog alpha; heterochromatin protein 1-alp |
Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
Immunogen | Reported variants represent identical protein: NP_036249.1, NP_001120793.1, NP_001120794.1 |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Goat anti-CBX5 / HP1-Alpha, biotinylated Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CBX5 |
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Synonyms | HP1A |
Function | Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. |
Cellular Location | Nucleus. Chromosome. Chromosome, centromere Note=Colocalizes with HNRNPU in the nucleus (PubMed:19617346) Component of centromeric and pericentromeric heterochromatin Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase (PubMed:19617346) Localizes to sites of DNA damage (PubMed:28977666) |
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