Goat anti-SSP29 / ANP32B, Biotinylated Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, Pep-ELISA |
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Primary Accession | Q92688 |
Other Accession | NP_006392.1 |
Reactivity | Human, Mouse, Rat, Pig, Dog, Bovine |
Host | Goat |
Clonality | Polyclonal |
Clone Names | ANP32B |
Calculated MW | 28788 Da |
Gene ID | 10541 |
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Other Names | ANP32B; acidic nuclear phosphoprotein 32 family member B; APRIL; PHAPI2; SSP29; acidic (leucine-rich) nuclear phosphoprotein 32 family, member B; acidic protein rich in leucines; putative HLA-DR-associated protein I-2; silver-stainable protein SSP29 |
Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
Immunogen | This antibody does NOT recognize theTNF family member also known as APRIL - Gene ID number 8741. However this antibody may cross-react with ANP32A (GeneID 8125). |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Goat anti-SSP29 / ANP32B, Biotinylated Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ANP32B |
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Synonyms | APRIL, PHAPI2 |
Function | Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:20015864, PubMed:18039846). Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:20015864). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (PubMed:20538007, PubMed:18039846). Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (PubMed:17178712). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity). |
Cellular Location | [Isoform 1]: Nucleus. Cytoplasm Note=Accumulates in the nuclei at the S phase. |
Tissue Location | Expressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta. |
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