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ANP32B Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q92688 |
| Other Accession | Q3SZC6, NP_006392.1, Q6A1I3 |
| Reactivity | Human |
| Predicted | Bovine, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 28788 Da |
| Antigen Region | 17-45 aa |
| Gene ID | 10541 |
|---|---|
| Other Names | Acidic leucine-rich nuclear phosphoprotein 32 family member B, Acidic protein rich in leucines, Putative HLA-DR-associated protein I-2, PHAPI2, Silver-stainable protein SSP29, ANP32B, APRIL, PHAPI2 |
| Target/Specificity | This ANP32B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-45 amino acids from the N-terminal region of human ANP32B. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ANP32B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ANP32B |
|---|---|
| Synonyms | APRIL, PHAPI2 |
| Function | Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:18039846, PubMed:20015864). Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:20015864). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (PubMed:18039846, PubMed:20538007). Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (PubMed:17178712). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity). |
| Cellular Location | [Isoform 1]: Nucleus. Cytoplasm Note=Accumulates in the nuclei at the S phase. |
| Tissue Location | Expressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity).
References
Tochio, N., et al. J. Mol. Biol. 401(1):97-114(2010)
Shen, S.M., et al. Carcinogenesis 31(3):419-426(2010)
Chemnitz, J., et al. Eur. J. Immunol. 39(1):267-279(2009)
Munemasa, Y., et al. Mol. Cell. Biol. 28(3):1171-1181(2008)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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