Goat anti-PTGES2 (aa292-306) Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, Pep-ELISA |
---|---|
Primary Accession | Q9H7Z7 |
Other Accession | NP_079348.1, NP_945176.1 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Clone Names | PTGES2 |
Calculated MW | 41943 Da |
Gene ID | 80142 |
---|---|
Other Names | PTGES2; prostaglandin E synthase 2; C9orf15; GBF-1; GBF1; PGES2; mPGES-2; GATE-binding factor 1; gamma-interferon-activated transcriptional element-binding factor 1; membrane-associated prostaglandin E synthase 2; microsomal prostaglandin E synthase-2 |
Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
Immunogen | This antibody is expected to recognize both reported isoforms (NP_079348.1; NP_945176.1). Reported variants represent identical protein: NP_001243264.1, NP_945176.1. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Goat anti-PTGES2 (aa292-306) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PTGES2 |
---|---|
Synonyms | C9orf15, PGES2 |
Function | Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) (PubMed:12804604, PubMed:18198127, PubMed:17585783). The biological function and the GSH- dependent property of PTGES2 is still under debate (PubMed:18198127, PubMed:17585783). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy- 5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (PubMed:17585783) (By similarity). |
Cellular Location | Golgi apparatus membrane; Single-pass membrane protein |
Tissue Location | Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.