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PTGES2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant PTGES2.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H7Z7 |
| Other Accession | NM_025072 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 5B7 |
| Calculated MW | 41943 Da |
| Gene ID | 80142 |
|---|---|
| Other Names | Prostaglandin E synthase 2, Membrane-associated prostaglandin E synthase-2, mPGE synthase-2, Microsomal prostaglandin E synthase 2, mPGES-2, Prostaglandin-H(2) E-isomerase, Prostaglandin E synthase 2 truncated form, PTGES2, C9orf15, PGES2 |
| Target/Specificity | PTGES2 (NP_079348, 270 a.a. ~ 377 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | PTGES2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene.
References
Microsomal prostaglandin E synthase-2: cellular distribution and expression in Alzheimer's disease. Chaudhry U, et al. Exp Neurol, 2010 Jun. PMID 19664621.Microsomal prostaglandin E synthase protein levels correlate with prognosis in colorectal cancer patients. Seo T, et al. Virchows Arch, 2009 Jun. PMID 19412621.Association analysis between the prostaglandin E synthase 2 R298H polymorphism and body mass index in 8079 participants of the KORA study cohort. Fischer A, et al. Genet Test Mol Biomarkers, 2009 Apr. PMID 19371221.The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES are all overexpressed in human gliomas. Mattila S, et al. Neuropathology, 2009 Apr. PMID 19347995.Determination of genetic predisposition to patent ductus arteriosus in preterm infants. Dagle JM, et al. Pediatrics, 2009 Apr. PMID 19336370.
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